Abstract
DNA polymerase purified from an E. coli strain with a pol mutation has been shown to differ from purified wild type enzyme in several characteristics. This result demonstrates that the pol gene is the structural gene for DNA polymerase.
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References
De Lucia, P., and Cairns, J., Nature, 224, 1164 (1969).
Gross, J., and Gross, M., Nature, 224, 1166 (1969).
Gross, J., Proc. Tenth Intern. Cong. Microbiol., Mexico City (1970).
Jovin, T. M., Englund, P. T., and Bertsch, L. L., J. Biol. Chem., 244, 2996 (1969).
Richardson, C. C., Schildkraut, C. L., Aposhian, H. V., and Kornberg, A., J. Biol. Chem., 222, 239 (1964).
Weber, K., and Osborn, M., J. Biol. Chem., 244, 4406 (1969).
Bollum, F. J., in Proc. Nucleic Acid Res. (edit. by Cantoni, G. L., and Davies, D. R.), 296 (Harper and Row, New York, 1966).
Richardson, C. C., in Proc. Nucleic Acid Res. (edit. by Cantoni, G. L., and Davies, D. R.), 264 (Harper and Row, New York, 1966).
Levine, L., in Handbook of Experimental Immunology (edit. by Weir, D. M.), 707 (Blackwell, Edinburgh, 1967).
Kornberg, T., and Gefter, M., Biochem. Biophys. Res. Commun., 40, 1348 (1970).
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KELLEY, W., WHITFIELD, H. Purification of an Altered DNA Polymerase from an E. coli Strain with a pol Mutation. Nature 230, 33–36 (1971). https://doi.org/10.1038/230033a0
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DOI: https://doi.org/10.1038/230033a0
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