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Effect of Pregnancy on the Isoantibody Response in Rabbits

Nature volume 233, pages 62–63 (1971)Cite this article

Abstract

WHEN an Rh-negative woman becomes pregnant for the first time with an Rh-positive foetus, the immune response to Rh-positive foetal red cells entering the maternal circulation is usually manifested by the appearance of antibodies after delivery or by priming without detectable antibodies, which only appear during a subsequent Rh-positive pregnancy1. The appearance of antibodies during the first pregnancy, in the absence of any known prior stimulus with Rh-positive blood, is not as rare as was formerly thought. A minimum of 1% of such women can be found to have antibodies at the end of the first preganancy, and they appear during the later months of ABO-compatible pregnancies2.

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Authors and Affiliations

  1. Nuffield Unit of Medical Genetics, Department of Medicine, University of Liverpool,

    J. C. WOODROW, C. J. ELSON & W. T. A. DONOHOE

Authors
  1. J. C. WOODROW
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  2. C. J. ELSON
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  3. W. T. A. DONOHOE
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WOODROW, J., ELSON, C. & DONOHOE, W. Effect of Pregnancy on the Isoantibody Response in Rabbits. Nature 233, 62–63 (1971). https://doi.org/10.1038/233062a0

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