Abstract
HYPERGAMMAGLOBULINAEMIA is common in SJL/J mice1,2, an inbred strain which develops spontaneously a high incidence of lymphoma3 and amyloidosis4. A number of the immunoglobulin elevations are electrophoretically indistinguishable from the “M” proteins seen in multiple myeloma1, but most are broadly dispersed electrophoretically and involve a single immunoglobulin fraction with elevations occurring as early as 6 weeks of age4. Less frequently, two and occasionally three or more fractions are increased5,6.
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HILL, R., BAKEMEIER, R., EASTCOTT, J. et al. Effects of Cyclophosphamide on Serum Immunoglobulin Levels in SJL/J Mice. Nature 234, 558–560 (1971). https://doi.org/10.1038/234558a0
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DOI: https://doi.org/10.1038/234558a0
