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Phenylalanine Metabolism altered by Dietary Dieldrin

Abstract

CHANGES in the metabolism of phenylalanine have been related to altered homeostasis of brain enzymes and mental deficiency in mammals1. Little is known, however, about the situation in fish, and we wish to describe the chronic effects of the pesticide dieldrin on these metabolic pathways in the rainbow trout (Salmo gairdneri). According to the National Pesticide Monitoring Program2, this is one of the most prevalent pesticides in the aquatic environment, having been found in 93% of fish samples from across the United States in concentrations of 0.01 to 1.6 µg/g (p.p.m.).

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MEHRLE, P., DECLUE, M. & BLOOMFIELD, R. Phenylalanine Metabolism altered by Dietary Dieldrin. Nature 238, 462–463 (1972). https://doi.org/10.1038/238462a0

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