Abstract
ACCORDING to the Lyon hypothesis the somatic cells of female mammals are functional mosaics with the X chromosome of maternal origin active in some cells and the paternal X active in the remainder1. Lyon also postulated that inactivation of X chromosomes occurs in early embryonic development and implied that, once inactivation occurs in any one cell, all descendants of that cell carry the same inactive X chromosome.
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HOPPE, P., WHITTEN, W. Does X Chromosome Inactivation Occur during Mitosis of First Cleavage?. Nature 239, 520 (1972). https://doi.org/10.1038/239520a0
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DOI: https://doi.org/10.1038/239520a0
