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STI-571 must select for drug-resistant cells but ‘no cell breathes fire out of its nostrils like a dragon’

Leukemia volume 16, pages 570–572 (2002)Cite this article

Abstract

Seemingly disappointing, the Bcr-Abl kinase inhibitor STI-571 shares an ‘unfortunate’ characteristic with conventional cancer drugs: the development of drug resistance. I argue that the resistance must develop even faster to STI-571 than to conventional drugs, because STI-571 is so effective. This is predictable, but is it inevitable? And how do mechanisms of resistance in relapse depend on a degree of remission. In addition to mutation rate and number of tumor cells, one additional factor determines relapse vs ‘extinction’ of the leukemia cell population.

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  1. MD and Department of Medicine, Medicine Branch, National Cancer Institute, NIH, Bethesda, New York Medical College, Valhalla, NY, USA

    MV Blagosklonny

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  1. MV Blagosklonny
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Blagosklonny, M. STI-571 must select for drug-resistant cells but ‘no cell breathes fire out of its nostrils like a dragon’. Leukemia 16, 570–572 (2002). https://doi.org/10.1038/sj.leu.2402409

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