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Stem cells and diversity

Leukemia volume 17, pages 1042–1048 (2003)Cite this article

Modern hematology began with two technology-based revolutions. First, assays were developed for cells earlier in lineages than those recognized morphologically. These opened for study important areas such as regulation and response to injury. Second, the rapid development of molecular biology disclosed complex mechanisms within cells and identified important genetic changes in malignancy. When immediate causative lesions were found, specific treatments directed at them were seen to be highly effective.

Recently, several groups have provided evidence of the existence in adult tissues of stem cells that are capable of differentiation into such diverse organ systems as hematopoiesis, muscle, liver and brain. The implications of this stem cell plasticity are just beginning to be realized.

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    E A McCulloch

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McCulloch, E. Stem cells and diversity. Leukemia 17, 1042–1048 (2003). https://doi.org/10.1038/sj.leu.2402948

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