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Human Lymphocyte Antigen Association in Ankylosing Spondylitis

Nature volume 242, page 121 (1973)Cite this article

Abstract

A STUDY of human lymphocyte phenotypes in unrelated Caucasian individuals with ankylosing spondylitis has revealed a striking similarity in their antigenic pattern. The lymphocytes of fifty such patients, when tested against a panel of twenty-six different specific typing sera, using a two stage lymphocytotoxicity micro-method, were shown to have in common either the antigen HL-A27 (96%) or the antigen W5 (4%). This remarkably high frequency of the antigen HL-A27 compares with the incidence of 5–6% of this antigen in random Caucasian populations.

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References

  1. Amos, D. B., Fifth International Histocompatibility Testing Workshop, Evian, May 1972.

    Google Scholar 

  2. Gofton, J. P., Bennett, P. H., Smythe, H. A., and Decker, J. L., Ann. Rheum. Dis., 31, 474 (1972).

    Article  CAS  Google Scholar 

  3. Baum, J., and Ziff, M., Arthritis Rheumatism, 13, 305 A (1970).

    Google Scholar 

  4. Amiel, J. L., Histocompatibility Testing 1967, 79 (Munksgaard, Copenhagen, 1967).

    Google Scholar 

  5. Zervas, J. D., Delamore, I. W., and Israels, M. C. G., Lancet, ii, 634 (1970).

  6. Falk, J., and Osoba, D., Lancet, ii, 1118 (1971).

  7. McDevitt, H. O., and Bodmer, W. F., Amer. J. Med., 52, 1 (1972).

    Article  CAS  Google Scholar 

  8. Walford, R. L., Smith, G. S., and Waters, H., Transplant. Rev., 7, 78 (1971).

    CAS  PubMed  Google Scholar 

  9. Stokes, P. L., Asquith, P., Holmes, G. K. T., Mackintosh, P., and Cooke, W. T., Lancet, ii, 162 (1972).

  10. Russell, T. J., Lorain, M. D., Schults, M., and Kuban, D. J., New England J. Med., 287, 738 (1972).

    Article  CAS  Google Scholar 

  11. Mickey, M. R., Kreisler, M., and Terasaki, P. I., Histocompatibility Testing 1970, 237 (Munksgaard, Copenhagen, 1970).

    Google Scholar 

  12. Kueppers, F., Brackertz, D., and Mueller-Eckhardt, C. H., Lancet, ii, 1425 (1972).

  13. Seignalet, J., Clot, J., Sany, J., and Serre, H., Vox Sanguinis, 23, 468 (1972).

    Article  CAS  Google Scholar 

  14. Lawler, S. D., and Klouda, P. T., Brit. J. Haematol., 21, 595 (1971).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Tissue Typing Laboratory, Blood Transfusion Unit, Westminster Hospital, London, SW1

    MAEVE F. P. CAFFREY & D. C. O. JAMES

Authors
  1. MAEVE F. P. CAFFREY
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  2. D. C. O. JAMES
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CAFFREY, M., JAMES, D. Human Lymphocyte Antigen Association in Ankylosing Spondylitis. Nature 242, 121 (1973). https://doi.org/10.1038/242121a0

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