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L-DOPA: Effect on Ethanol Narcosis and Brain Biogenic Amines in Mice

Abstract

L-DOPA augments ethanol-induced narcosis in mice1. Determination of brain biogenic amines suggested that the enhancement effect may be due in part to the marked increase in brain dopamine following L-DOPA administration. Here we provide further evidence to implicate dopamine in L-DOPA-induced augmentation of ethanol narcosis.

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BLUM, K., CALHOUN, W., MERRITT, J. et al. L-DOPA: Effect on Ethanol Narcosis and Brain Biogenic Amines in Mice. Nature 242, 407–409 (1973). https://doi.org/10.1038/242407a0

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