Abstract
THE structures of more than 100 variant human haemoglobins have been determined and in many cases it has been possible to relate the position of the individual amino-acid substitution to the stability and function of the molecule1,2. Here we describe the amino-acid replacement, structural alterations and oxygenation properties of a variant, haemoglobin-Camden, which has a substitution in the α1β1 intersubunit contact of the haemoglobin molecule.
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WADE COHEN, P., YATES, A., BELLINGHAM, A. et al. Amino-acid Substitution in the α1β1 Intersubunit Contact of Haemoglobin-Camden β131 (H9) Gln→Glu. Nature 243, 467–468 (1973). https://doi.org/10.1038/243467a0
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DOI: https://doi.org/10.1038/243467a0
