Abstract
THE mechanism whereby thymus-derived (T) and bone marrow or bursa-derived (B) lymphocytes cooperate in the induction of an antibody response is of great importance in immunology. It has been suggested that T cells concentrate antigen by their surface receptors to present a multideterminant antigen array directly to B cells1,2; or that T cells secrete a special class of cooperating antibody (IgX) for this purpose, which could specifically present antigen at the surface of a third cell, the macrophage3,4; or that the product of recognition of antigen by T cells has some non-specific mitogenic or stimulatory effect on B cells5,6. Recent work with in vitro systems has indicated that various factors produced by T cells, either after contact with a specific antigen or following stimulation by allogeneic cells, can replace the requirement for T cells in antibody formation7–14.
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References
Mitchison, N. A. in Immunological Tolerance (edit. by Landy, M. and Braun, W.) 115 (Academic, London and New York, 1969).
Mitchison, N. A., Rajewsky, K., and Taylor, R. B., in Developmental Aspects of Antibody Formation and Structure (edit. by Sterzl, J. and Riha, I.) 547 (Academic, London and New York, 1970).
Taussig, M. J., and Lachmann, P. J., Immunology, 22, 185 (1972).
Feldmann, M., and Nossal, G. J. V., Transpln. Rev., 13, 3 (1972).
Katz, D. H., and Benacerraf, B., Adv. Immun., 15, 2 (1972).
Kreth, H. W., and Williamson, A. R., Nature, 234, 454 (1971).
Feldmann, M., and Basten, A., Nature new Biol., 237, 13 (1972).
Schimpl, A., and Wecker, E., Nature new Biol., 237, 15 (1972).
Ekpaha-Mensah, A., and Kennedy, J. C., Nature new Biol., 233, 174 (1971).
Dutton, R. W., Falkoff, R., Hirst, J. A., Hoffmann, M., Kappler, J. W., Kettman, J. R., Lesley, J. F., and Vann, D., in Progress in Immunology (edit. by Amos, B.) 355 (Academic, London and New York, 1971).
Gorczynski, R. M., Miller, R. G., and Phillips, R. A., J. Immun., 110, 968 (1973).
Britton, S., Scand. J. Immun., 1, 89 (1972).
Katz, D. H., Transpln. Rev., 12, 141 (1972).
Waldmann, H., and Munro, A., Nature, 243, 356 (1973).
Von Boehmer, H., and Shortman, K., J. Immun. Meth., 2, 293 (1973).
Möller, G., Cell. Immun., 1, 573 (1970).
Coutinho, A., and Möller, G., Nature new Biol., 245, 12 (1973).
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TAUSSIG, M. T cell factor which can replace T cells in vivo. Nature 248, 234–236 (1974). https://doi.org/10.1038/248234a0
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DOI: https://doi.org/10.1038/248234a0
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