Abstract
ONE unifying hypothesis of the behavioural effects produced by neuroleptic drugs is that they act by blocking dopamine receptors in the central nervous system1–3. Neuroleptic drugs produce increases in dopamine turnover4, increase accumulation of its metabolites5, antagonise amphetamine induced behaviour in man and animals6 and block the stimulating effects of dopamine on cyclic AMP production in homogenates of rat brain striatum or mesolimbic nuclei7–9.
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References
Matthysse, S., Fedn Proc., 32, 200–205 (1973).
Van Rossum, J. M., Arch. int. Pharmacodyn., 160, 492–494 (1960).
Horn, A. S., and Snyder, S. H., Proc. natn. Acad. Sci., U.S.A., 68, 2325–2328 (1971).
Nyback, H., Borzecki, Z., and Sedvall, G., Eur. J. Pharmac., 4, 395–403 (1968).
Anden, N.-E., Roos, B.-E., and Werdinius, B., Life Sci., 3, 149–158 (1964).
Snyder, S. H., Arch. gen. Psychiat., 27, 169–179 (1972).
Kebabian, J. W., Petzold, G. L., and Greengard, P., Proc. natn. Acad. Sci., U.S.A., 69, 2145–2149 (1972).
Miller, R. J., and Iversen, L. L., Trans. Biochem. Soc., (in the press).
Horn, A. S., Cuello, A. C., and Miller, R. J., J. Neurochem., (in the press).
Hornykiewicz, O., Pharmac. Rev., 18, 925–964 (1966).
Klawans, H. L., The Pharmacology of Extrapyramidal Movement Disorders. Monographs in neural sciences 2., (edit. by Cohen, M.) (Karger, Basel, 1973).
Freyhan, F. A., in Extrapyramidal System and Neuroleptics (edit. by Bordeleau, J. M.) 483–486 (Editions Psychiatriques, Montreal, 1961).
Klein, D. F., and Davis, J. M., Diagnosis, and Drug Treatment of Psychiatric Disorders (Williams and Wilkins, Baltimore, 1969).
Shader, R. I., and Di Mascio, A., Psychotropic Drug Side Effects (Williams and Wilkins, Baltimore, 1970).
Stille, G., and Hippius, A., Pharmacopsychiatry, 4, 182–191 (1971).
Anden, N.-E., J. Pharm. Pharmac., 24, 905–906 (1972).
Anden, N.-E., J. Pharm. Pharmac., 25, 346–348 (1973).
Stille, G., Lauener, H., and Eichenberger, E., Il Farmaco, 26, 603–625 (1971).
Lowry, O. H., Rosebrough, N. H., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).
Burgen, A. S. V., Hiley, C. R., and Young, J. M., Br. J. Pharmac., (in the press).
Burgen, A. S. V., Hiley, C. R., and Young, J. M., Br. J. Pharmac., (in the press).
Crow, T. J., and Gillbe, C., Nature, 245, 27–28 (1973).
Snyder, S. H., Greenberg, D., and Yamamura, H. I., Arch. gen. Psychiat., (in the press).
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MILLER, R., HILEY, C. Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism. Nature 248, 596–597 (1974). https://doi.org/10.1038/248596a0
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DOI: https://doi.org/10.1038/248596a0
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