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[Letters to nature]

Nature volume 255, pages 243–244 (1975)Cite this article

Abstract

WE report here the occurrence of somatic chromosome translocations in lymphocytes from individuals studied for clinical cytogenetic diagnosis. We note that these translocations are non-random in composition and resemble those in ataxia-telangiectasia (A-T) lymphocyte clones1. Our data have been collated with information from two other centres (Halifax and Atlanta) reported in this issue2,3 to provide a preliminary estimate of the frequency of chromosome translocations in cultured lymphocytes.

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References

  1. Hecht, F., McCaw, B. K., and Koler, R. D., New Engl. J. Med., 289, 286–291

  2. Welch, J. P., and Lee, C. L. Y., Nature, 255, 777 (1975).

    Article  Google Scholar 

  3. Beatty-DeSana, J. W., Hoggard, M. J., and Cooledge, J. W., Nature, 255, 777 (1975).

    Article  Google Scholar 

  4. Paris Conference (1971) Standardization in Human Cytogenetics, Birth Defects: Original Article Series, XIII (7) (The National Foundation, New York, 1972).

  5. Jacobs, P. A., Frackiewicz, A., and Law, P., Ann. Hum. Genet., 35, 301–319 (1972).

    Article  CAS  Google Scholar 

  6. Hecht, F., and Kimberling, W. J., Am. J. hum. Genet., 23, 361–367 (1971).

    CAS  PubMed  Google Scholar 

  7. Hecht, F., et al., Science, 161, 371–372 (1968).

    Article  ADS  CAS  Google Scholar 

  8. McCaw, B. K., Hecht, F., Harnden, D. G., and Teplitz, R., Proc. natn. Acad. Sci. U.S.A. (in the press).

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Authors and Affiliations

  1. Department of Pediatrics and Division of Medical Genetics, Child Development and Rehabilitation Center, University of Oregon Medical School, Portland, Oregon, 97201

    FREDERICK HECHT & BARBARA KAISER McCAW

  2. Department of Biophysics and Genetics, University of Colorado Medical Center, Denver, Colorado, 80220

    DAVID PEAKMAN & ARTHUR ROBINSON

Authors
  1. FREDERICK HECHT
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  2. BARBARA KAISER McCAW
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  3. DAVID PEAKMAN
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  4. ARTHUR ROBINSON
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HECHT, F., McCAW, B., PEAKMAN, D. et al. [Letters to nature]. Nature 255, 243–244 (1975). https://doi.org/10.1038/255243a0

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