Abstract
Possible causal factors of denervation-induced changes in muscle include inactivity, products of nerve degeneration and lack of a nerve-borne trophic agent. We now show that if the innervated fibres in a partially denervated rat muscle are rendered inactive, they undergo a reaction as intense as that of the denervated fibres. This provides further support for the view that the effects of denervation on the extrajunctional muscle membrane result from a combination of muscle inactivity and of nerve breakdown products acting diffusely throughout the muscle.
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Cangiano, A., Lutzemberger, L. Partial denervation in inactive muscle affects innervated and denervated fibres equally. Nature 285, 233–235 (1980). https://doi.org/10.1038/285233a0
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DOI: https://doi.org/10.1038/285233a0
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