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Controlled transcription of a human α-interferon gene introduced into mouse L cells

Nature volume 297, pages 128–132 (1982)Cite this article

Abstract

Mouse L cells were transformed with a cloned chromosomal human interferon-α1 gene, linked to a herpes thymidine kinase gene as selectable marker. In 8 out of 12 cell lines containing the human interferon gene, infection with Newcastle disease virus stimulated synthesis of messenger RNA for the human interferon—in parallel with that of the endogenous mouse interferon genes.

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Authors and Affiliations

  1. Institut für Molekularbiologie I, Universität Zürich, Hönggerberg, Zürich, 8093, Switzerland

    Ned Mantei & Charles Weissmann

Authors
  1. Ned Mantei
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  2. Charles Weissmann
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Mantei, N., Weissmann, C. Controlled transcription of a human α-interferon gene introduced into mouse L cells. Nature 297, 128–132 (1982). https://doi.org/10.1038/297128a0

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