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Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA

Nature volume 302, pages 114–119 (1983)Cite this article

Abstract

A transforming gene detected by transfection of chicken B-cell lymphoma DNA has been isolated by molecular cloning. It is homologous to a conserved family of sequences present in normal chicken and human DNAs but is not related to transforming genes of acutely transforming retroviruses. The nucleotide sequence of the cloned transforming gene suggests that it encodes a protein that is partially homologous to the amino terminus of transferrin and related proteins although only about one tenth the size of transferrin.

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Authors and Affiliations

  1. Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Gerard Goubin, Debra S. Goldman & Geoffrey M. Cooper

  2. Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Gerard Goubin & Geoffrey M. Cooper

  3. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Debra S. Goldman

  4. The Fred Hutchinson Cancer Research Center, Departments of Medicine and Pathology, University of Washington, Seattle, Washington, 98104, USA

    Judith Luce & Paul E. Neiman

Authors
  1. Gerard Goubin
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  2. Debra S. Goldman
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  3. Judith Luce
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  4. Paul E. Neiman
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  5. Geoffrey M. Cooper
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Goubin, G., Goldman, D., Luce, J. et al. Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA. Nature 302, 114–119 (1983). https://doi.org/10.1038/302114a0

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