Abstract
The invariant (Ii) chain of murine Ia antigens is associated with the intracellular but not the cell-surface forms of the Aα:Aβ and Eα:Eβ Ia complexes1–3. Due to its unique subcellular localization, Ii has been postulated to play a part in the assembly4 or intraceUular transport2 of the Ia α:β complexes, which function in immune recognition5–7. A more general role for Ii in the transport of other cell proteins has also been suggested8. Because of the unusual subunit composition of Ia antigens and because the synthesis of α, β and Ii chains is coordinately regulated9, it was of interest to determine whether, like the α and β chains10–12, Ii is encoded by a gene in the I region of the H–2 histocompatibility complex. We report here the use of an Ii chain polymorphism present in Mus spretus13 to demonstrate that the gene for Ii is not linked to the H–2 complex. Thus, intracellular Ia antigens consist of the products of two linked genes and one unlinked gene.
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Day, C., Jones, P. The gene encoding the Ia antigen-associated invariant chain (Ii) is not linked to the H–2 complex. Nature 302, 157–159 (1983). https://doi.org/10.1038/302157a0
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DOI: https://doi.org/10.1038/302157a0
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