Abstract
Objective: To investigate the relationship between serum cystatin C, serum creatinine, and 51Cr-EDTA-clearance in patients with spinal cord injury.
Setting: The Spinal Cord Unit, Viborg-Kjellerup County Hospital.
Methods: Twenty-four men and seven women aged 20.3 to 68.0 years with motor complete spinal cord injury (ASIA A or B) were included. Serum cystatin C was measured by an automated particle-enhanced nephelometric immunoassay (Dade Behring), serum creatinine by an enzymatic method (Vitros 950), and 51Cr-EDTA-clearance by a multiple plasma sample method.
Results: A linear relationship was found between 51Cr-EDTA-clearance and the reciprocal values of cystatin C and creatinine. The correlation coefficient between 51Cr-EDTA-clearance and 1/cystatin C was 0.72 compared to the correlation coefficient between 51Cr-EDTA-clearance and 1/creatinine being 0.26. Comparison of the area under the curves in the non-parametric receiver operating characteristics (ROC) plots for serum cystatin C (area under the curve (AUC)=0.912; SE=0.065), and serum creatinine (AUC=0.507; SE=0.115) revealed significant differences (P-values=0.0005).
Conclusion: In patients with spinal cord injury serum cystatin C is a better marker of the renal function compared to serum creatinine.
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Acknowledgements
The study has been supported by grants from Helen and Ejnar Bjørnows Foundation. The authors are grateful to Mrs Mette Kjelst and Mrs Lilian Christensen for their technical assistance.
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Thomassen, S., Johannesen, I., Erlandsen, E. et al. Serum cystatin C as a marker of the renal function in patients with spinal cord injury. Spinal Cord 40, 524–528 (2002). https://doi.org/10.1038/sj.sc.3101320
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DOI: https://doi.org/10.1038/sj.sc.3101320
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