Abstract
Study design:
A controlled single-case design: A1 (baseline: 6 weeks), B (intervention:12 weeks of treadmill training (TT), maximally five times a week/30 min a day), A2 (wash-out: 6 weeks), follow-up measurement: 6 months.
Objective:
To investigate the effects of TT on functional health status (FHS) and quality of life (QoL) in subjects with a chronic incomplete spinal cord injury (ISCI).
Setting:
Rehabilitation Department, University Medical Centre Utrecht, The Netherlands.
Methods:
Three male subjects with a stable (>48 months postinjury) ISCI, American Spinal Injury Association (ASIA) class C (n=2) and D (n=1). Performance-based walking, subject's perception concerning quality of life (SEIQoL) and activities of daily living Canadian Occupational Performance Measure (COPM).
Results:
The results of the three subjects were variable. Changes in QoL were relatively small and diverse. After 6 months' follow-up, QoL was unchanged in subjects 1 and 2, and improved in subject 3. In subject 2, performance of activities of daily living (ADL) was significantly improved, consistent with his perception of improvement (P<0.05), and this improvement was sustained throughout the follow-up period. Walking ability improved in subject 3 (P<0.05) but performance of other activities remained stable. Performance of ADL decreased slightly in subject 1 whereas his walking speed and Get up and Go performance improved (P<0.05).
Conclusions:
This study demonstrates positive effects of TT on FHS. A randomised clinical trial should be executed before definite conclusions about the effect of TT on FHS and QoL can be drawn.
Sponsorship:
KF Hein Foundation and Rehabilitation Centre De Hoogstraat Scientific Foundation.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Brissot R et al. Clinical experience with functional electrical stimulation-assisted gait with parastep in spinal cord-injured patients. Spine 2000; 25: 501–508.
Penn RD et al. Intrathecal baclofen for severe spinal spasticity. N Engl J Med 1989; 320: 1517–1521.
Wernig A, Nanassy A, MĂ¼ller S . Maintenance of locomotor abilities following Laufband (treadmill) therapy in para-and tetraplegic persons: follow-up studies. Spinal Cord 1998; 36: 744–749.
Wernig A, Nanassy A, MĂ¼ller S . Laufband (Treadmill) therapy in incomplete paraplegia and tetraplegia. J Neurotrauma 1999; 16: 719–724.
Barbeau H et al. Does neurorehabilitation play a role in the recovery of walking in neurological populations? Ann NY Acad Sci 1998; 860: 377–392.
Harkema SJ, Dobkin BH, Edgerton VR . Pattern generators in locomotion: implications for regeneration after spinal cord injury. Top Spinal Cord Inj Rehabil 2000; 6: 82–96.
Dietz V, Wirz M, Curt A, Colombo G . Locomotor pattern in paraplegic patients: training effects and recovery of spinal cord function. Spinal Cord 1998; 36: 380–390.
Dietz V, Nakazawa K, Wirz M, Erni T . Level of spinal cord lesion determines locomotor activity in spinal man. Exp Brain Res 1999; 128: 405–409.
De Leon RD, Roy RR, Edgerton VR . Is the recovery of stepping following spinal cord injury mediated by modifying existing neural pathways or by generating new pathways? A perspective. Phys Ther 2001; 81: 1904–1911.
World Health Organisation. International Classification of Functioning, Disability and Health: ICF. WHO: Geneva 2001.
Pépin A, Norman KE, Barbeau H . Treadmill walking in incomplete spinal-cord-injured subjects: 1. Adaptation to changes in speed. Spinal Cord 2003; 41: 257–270.
Pépin A, Ladouceur M, Barbeau H . Treadmill walking in incomplete spinal-cord-injured subjects: 2. Factors limiting the maximal speed. Spinal Cord 2003; 41: 271–279.
Behrman AL, Harkema SJ . Locomotor training after human spinal cord injury: a series of case studies. Phys Ther 2000; 80: 688–700.
Verbrugge LM, Jette AM . The disablement process. Soc Sci Med 1994; 38: 1–14.
Jette AM, Keysor JJ . Disability models: implications for arthritis exercise and physical activity interventions. Arthr Rheum 2003; 49: 114–120.
Field-Fote EC . Combined use of body weight support, functional electric stimulation, and treadmill training to improve walking ability in individuals with chronic incomplete spinal cord injury. Arch Phys Rehabil 2001; 82: 818–824.
Maynard FM et al. International standards for neurological and functional classification of spinal cord injury. American Spinal Injury Association. Spinal Cord 1997; 35: 266–274.
O' Boyle CA, McGee HM, Joyce CRB . Quality of life assessing the individual. Adv Med Soc 1994; 5: 159–180.
Law M et al. The Canadian occupational performance measure: results of pilot testing. Can J Occup Ther 1994; 61: 191–197.
Salvatory P, Baptiste S, Ward M . Development of a tool to measure clinical competence in occupational therapy: a pilot study? Can J Occup Ther 2000; 67: 51–60.
Clark C, Scott E, Krupa T . Involving clients in programme evaluation and research: a new methodology for occupational therapy. Can J Occup Ther 1993; 60: 192–199.
Sackley CM, Baguley BI, Gent S, Hodgson P . The use of a balance performance monitor and weight-transference in the treatment of weight-bearing problems after stroke. Phys Ther 1992; 78: 907–914.
Bateman A et al. The effect of aerobic training on rehabilitation outcomes after recent severe brain injury: a randomised controlled evaluation. Arch Phys Med Rehabil 2001; 82: 74–82.
Berg KO, Wood-Dauphinee SL, Williams JI, Maki B . Measuring balance in elderly: validation of an instrument. Can J Public Health 1992; 83 (Suppl 2): S7–S11.
Berg K, Wood-Dauphinee SL, Williams JI . The balance scale: reliability assessment with elderly residents and patients with an acute stroke. Scan J Rehabil Med 1995; 27: 27–36.
Goldie PA, Matyas TA, Evans OM . Deficit and change in gait velocity during rehabilitation after stroke. Arch Phys Med Rehabil 1996; 77: 1074–1082.
Brandstater ME, de Bruin H, Gowland C, Clark BM . Hemiplegic gait: analysis of temporal variables. Arch Phys Med Rehabil 1983; 64: 583–587.
Wade DT et al. Walking after stroke: measurement and recovery over the first three months. Scand J Rehab Med 1987; 19: 25–30.
Salbach NM et al. Responsiveness and predictability of gait speed and other disability measures in acute stroke. Arch Phys Med Rehabil 2001; 82: 1204–1212.
Mathias S, Nayak US, Isaacs B . Balance in elderly patients: the ‘Get up and Go’ test. Arch Phys Med Rehabil 1986; 67: 387–389.
Podsiadlo D, Richardson S . The timed ‘Up & Go’: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991; 39: 142–148.
Stein RB, Yang JF, Bélanger M, Pearson KG . Modification of reflexes in normal and abnormal movements. Prog Brain Res 1993; 97: 189–196.
Levin MF, Hui-Chan C . Ankle spasticity is inversely correlated with antagonist voluntary contraction in hemiparetic subjects. Electromyogr Clin Neurophysiol 1994; 34: 415–425.
Katz RT, Rovai GP, Brait C, Rymer WZ . Objective quantification of spastic hypertonia: correlation with clinical findings. Arch Phys Med Rehabil 1992; 73: 339–349.
Sköld C, Harms-Ringdahl K, Hultling C, Levi R, Seiger . Simultaneous Ashworth measurements and electromyographic recordings in tetraplegic patients. Arch Phys Med Rebabil 1998; 79: 959–965.
Gregson JM et al. Reliability of measurements of muscle tone and muscle power in stroke patients. Age Ageing 2000; 29: 223–228.
Blackburn M, van Vliet P, Mockett SP . Reliability of measurements obtained with the Modified Ashworth Scale in the lower extremities of people with stroke. Phys Ther 2002; 82: 25–34.
Nollet F, Beelen A . Strength assessment in postpolio syndrome: validity of a hand-held dynamometer in detecting change. Arch Phys Rehabil 1999; 80: 1316–1323.
Karner PM, Thompson AL, Connelly DM, Vandervoort AA . Strength testing in elderly women using a portable dynamometer. Physiother Can 1998; 78: 1095–1103.
Bohannon RW et al. Deficits in lower extremity muscle and gait performance among renal transplant candidates. Arch Phys Med Rehabil 1995; 76: 547–551.
Wagenaar RC . Functional recovery after stroke. Thesis/Dissertation, VU Amsterdam 1990.
Hojem MA, Ottenbacher KJ . Empirical investigation of visual-inspection versus trend-line analysis of single-subject data. Phys Ther 1988; 68: 983–988.
Edgington ES . Statistics and single case analyses. Prog Behav Mod 1984; 16: 83–119.
Acknowledgements
This study was supported by the KF Hein foundation and Rehabilitation Centre De Hoogstraat Scientific Foundation. We thank Eduard Blanken (MSc/PT) for his assistance with the training and measuring and Joop Faber (PhD/biostatistician) and Cas Kruitwagen (MSc/biostatistician) for their help with the statistical analyses.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Effing, T., van Meeteren, N., van Asbeck, F. et al. Body weight-supported treadmill training in chronic incomplete spinal cord injury: a pilot study evaluating functional health status and quality of life. Spinal Cord 44, 287–296 (2006). https://doi.org/10.1038/sj.sc.3101841
Published:
Issue date:
DOI: https://doi.org/10.1038/sj.sc.3101841
Keywords
This article is cited by
-
Real-time motion onset recognition for robot-assisted gait rehabilitation
Journal of NeuroEngineering and Rehabilitation (2022)
-
The effects of active upper-limb versus passive lower-limb exercise on quality of life among individuals with motor-complete spinal cord injury
Spinal Cord (2022)
-
Quality of life and psychological outcomes of body-weight supported locomotor training in spinal cord injured persons with long-standing incomplete lesions
Spinal Cord (2020)
-
Improvements in skilled walking associated with kinematic adaptations in people with spinal cord injury
Journal of NeuroEngineering and Rehabilitation (2019)
-
Individualised and health-related quality of life of persons with spinal cord injury
Spinal Cord (2014)


