Abstract
External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Barbacid, M. A. Rev. Biochem. 56, 779–827 (1987).
Satoh, T., Endo, M., Nakamura, S. & Kaziro, Y. FEBS Lett. 236, 185–189 (1988).
Satoh, T., Nakamura, S. & Kaziro, Y. Molec. cell. Biol. 7, 4553–4556 (1987).
Field, J., Broek, D., Kataoka, T. & Wigler, M. Molec. cell. Biol. 7, 2128–2133 (1987).
Sweet, R. W. et al. Nature 311, 273–275 (1984).
Der, C. J., Pan, B. T. & Cooper, G. M. Molec. cell. Biol. 6, 3291–3294 (1986).
Trahey, M. & McCormick, F. Science 238, 542–545 (1987).
Cantrell, D. A., Davies, A. A. & Crumpton, M. J. Proc. natn. Acad. Sci. U.S.A. 82, 8158–8162 (1985).
Gillis, S. & Watson, J. Immunol. Rev. 54, 81–109 (1981).
Weiss, A. & Imboden, J. B. Adv. Immun. 41, 1–38 (1987).
Beverley, P. C. L. & Callard, R. E. Eur. J. Immun. 11, 329–334 (1981).
Brattsand, G., Cantrell, D. A., Ward, S., Ivars, F. & Gulberg, M. J. Immun. 144, 3651–3658 (1990).
Rodriguez-Pena, A. & Rozengurt, E. EMBO J. 5, 77–83 (1986).
Graves, J. D., Lucas, S. C., Alexander, D. R. & Cantrell, D. A. Biochem. J. 265, 407–413 (1990).
Wolfman, A. & Macara, I. Science 248, 67–69 (1990).
West, M., Kung, H. & Kamata, T. FEBS Lett. 259, 245–248 (1990).
Downward, J., Riehl, R., Wu, L. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. (in the press).
Ballester, R., Furth, M. E. & Rosen, O. M. J. biol. Chem. 262, 2688–2695 (1987).
Molloy, C. J. et al. Nature 342, 711–714 (1989).
Ellis, C., Moran, M., McCormick, F. & Pawson, T. Nature 343, 377–381 (1990).
Downward, J., de Gunzburg, J., Riehl, R. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. 85, 5774–5778 (1988).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Downward, J., Graves, J., Warne, P. et al. Stimulation of p21ras upon T-cell activation. Nature 346, 719–723 (1990). https://doi.org/10.1038/346719a0
Received:
Accepted:
Issue date:
DOI: https://doi.org/10.1038/346719a0
This article is cited by
-
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium
Immunity & Ageing (2022)
-
CD6-mediated inhibition of T cell activation via modulation of Ras
Cell Communication and Signaling (2022)
-
Immune stimulation of rainbow trout reveals divergent regulation of MH class II-associated invariant chain isoforms
Immunogenetics (2019)
-
Lysophosphatidylcholine Drives Neuroblast Cell Fate
Molecular Neurobiology (2016)
-
RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics
Nature Immunology (2016)
