Figure 3

Genealogical tree of the clonal development in this composite lymphoma. Two hypothetical common ancestors (I and II) have been indicated. The number of shared or additional mutations in the different clones is given. KDE, kappa-deleting element; KDE unrearr., germline configuration of the KDE; JκKDE rearr., Jκ–Cκ intron–RSS/KDE rearrangement.