Figure 6
From: EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade
Expression of a constitutive form of MEK is sufficient for Ki67 expression and morphological modification of adult human duct cells. (a) Clusters of human duct cells were analyzed for spreading 5 days after adenoviral infection. Bar, 200 μm. (b) Ki67 expression was examined in cells cultured for 5 days following infection with adenovirus expressing GFP (Ad-GFP) or a constitutive active form of MEK (Ad-MEKca), followed by culture in the presence or absence of EGF. For each point, at least 500 cells from three different pancreata were counted. Data are expressed as mean±s.e.m.
