Table 3 Cilia and BBS
From: Cilium-generated signaling and cilia-related disorders
Gene | Protein property/function | Location | ||
|---|---|---|---|---|
Mammals | Worm/fly | Chlamydomonas | ||
BBS1 | Unknown function | Null mutant mice: no olfactory cilia but normal respiratory and renal cilia | Basal body and cilia in worm | C_1020033 |
BBS2 | Unknown function | No information | Basal body and cilia in worm | C_200109 |
BBS3 | Small G-protein | No information | Basal body and cilia in worm | C_970056 |
Transport along ciliary axoneme | ||||
BBS4 | Target/anchor pericentriolar protein PCM1 | Basal body and centrosomes | No information | C_70158 |
Loss results in disorganized microtubules, mislocalization of centriolar proteins, failure of cell division | ||||
Null mutant mice: no olfactory cilia but normal respiratory and renal cilia | ||||
BBS5 | Generation of cilia and flagella | Basal body | Basal body in worm | C_270058 |
RNAi knockdown cells aflagellate | ||||
BBS6 | Putative chaperonin | No information | No information | Not found |
Basal body and cilia in worm | ||||
BBS7 | Bidirectional movement along ciliary axoneme | Basal body | Compromised IFT, shortened cilia in worm mutant | C_1330001 |
BBS8 | 505aa; TPR domain | Centrosome, Basal body, cilia (retina, olfactory neurons, spermatids, bronchial epithelial cells) | Basal body and cilia in worm | C_970071 |
Associates with PCM1 | Loss of BBS8 protein in worm results in compromised IFT, shortened cilia | |||
Bidirectional movement along ciliary axoneme | ||||
