Figure 1
From: Expression of HSP47, a collagen-specific chaperone, in normal and diseased human liver
HSP47 is localized to sinusoidal lining cells in histologically normal and diseased human livers. Sections of livers were immunostained for HSP47 as described in the Materials and methods. (a) Low-power view of control liver showing diffuse HSP47 reactivity along the sinusoids throughout the lobule. (b) Higher magnification view of control liver illustrating the morphology of the HSP47-expressing sinusoidal lining cells. (c) Higher magnification view of a portal tract in control liver demonstrating HSP47 reactivity in the endothelium of the portal vein branch and hepatic arteriole, as well as in slender cells in the surrounding stroma. (d) HSP47-positive cells with a morphology similar to that of the portal tract stromal cells are evident within and surrounding a granuloma in a liver from a patient with primary biliary cirrhosis. (e) Low-power view of a cirrhotic liver showing intense septal HSP47 reactivity as well as a preserved pattern of sinusoidal lining cell HSP47 expression. (f) This higher magnification view of cirrhotic liver shows a portal tract that has been incorporated into fibrous septa; HSP47 reactivity is accentuated along the leading edges of the septa. Original magnifications × 10 (a, e), × 40 (b, d), × 20 (c, f).
