Figure 6 | Laboratory Investigation

Figure 6

From: Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase signaling in human endothelial cells

Figure 6

siRNA technology was used to block JNK expression in confluent EC. Untreated and control siRNA (siControl) treated confluent EC expressed both JNK and Hes-1 protein; while cells treated with the validated siRNA duplexes showed a significant decrease in both JNK (2.7-fold decrease, on average) and Hes-1 expression (6.75-fold decrease, on average). There was no effect of either siRNA on actin expression although there was a slight decrease in Hes-1 expression (1.26-fold on average) using the control siRNA.

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