Figure 1 | Laboratory Investigation

Figure 1

From: CD95 ligand-dependant endothelial cell death initiates oral mucosa damage in a murine model of acute graft versus host disease

Figure 1

Transfer of allogeneic lymphocytes induces body weight loss, a clinical feature of aGVHD. Immunodeficient SCID mice were injected with 2.5 × 107 lymphocytes from syngeneic wt mice or with 2.5 × 107 lymphocytes from either allogeneic wt mice, gld mice that are defective in CD95L, or lpr mice that are defective in CD95, but express functional CD95L. All allogeneic mice were from the same C57BL/6 genetic background. Body weight was measured for each mouse during a period of 14 days. Results are expressed as percentages of body weight loss, and are mean±s.d. of measurement in groups of six mice each.

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