Figure 2

Increased proliferation and decreased apoptosis in CC10-hASH1 mice contribute to remodeling in BADJ. (a) PCNA immunostaining of transgenic mouse TB epithelium revealed multiple positive nuclei (arrows). (b) Quantitation of BrdU labeling indexes (mean percent of positive cells ±s.e.m.) by the type of epithelium and age in WT and transgenic mice. Highest levels were noted in TBs of 1-month-old transgenic mice, followed by BOA at 4 months. (c) A bargraph of apoptotic index (mean percent of positive cells±s.e.m.), which was significantly lower in TBs of CC10-hASH1 mice than in TBs of WT mice. The index remained unchanged in BL. H, CC10-hASH1 transgenic mouse; m, month; N=0 (no labeling). The number of mice is given in parentheses. Statistical comparisons (b, c) between WT and transgenic mice in each age group and category of epithelium (BL, TB and BOA): ^*P<0.05, ^#P<0.01, ^&P<0.001.