Figure 4

(a) The number of CK-7-positive cholangiocytes in liver sections from 3- and 7-day KO BDL mice was reduced compared to 3- and 7-day WT BDL mice. Data are mean±s.e.m. of n=5 experiments. (b) PCNA protein expression in purified cholangiocytes from 3-day KO BDL mice was reduced compared with cholangiocytes from 3-day WT BDL mice. Data are mean±s.e.m. of eight experiments. #P<0.05 vs normal WT. *P<0.05 vs BDL WT.