Table 1 Serum CGRP levels, liver to body weight ratio, inflammation, necrosis, lobular damage, and cholangiocyte proliferation and apoptosis in wild-type and KO normal and 3-day BDL mice

	Normal WT	Normal KO	3-Day BDL WT	3-Day BDL KO
Liver weight (n=14)	1.6±0.04	1.6±0.1	1.5±0.04	1.3±0.07^b
Body weight (n=14)	23.4±0.4	23.3±1.0	19.2±0.35	20.8±0.8
Liver to body weight ratio (n=14)	7.1±0.3	7.1±1.0	7.9±0.3^a	6.1±0.4^b
Plasma CGRP levels (pg/ml)	31.1±3.6	11.8±2.4^a	65.0±5.4^a	25.5±3.7^b
Lobular damage	Not detected	Not detected	1.0±0.0	0.8±0.2^NS
Necrosis	Not detected	Not detected	0.6±0.2	0.6±0.2^NS
Portal inflammation	Not detected	Not detected	1.4±0.2	1.2±0.2^NS
Apoptosis (n=5)	0.0±0.0	0.2±0.2^NS	4.0±0.5^a	5.8±0.3^b

Data are mean±s.e.m. of cumulative values obtained from the evaluation of 10 portal tracts from three different slides for each group.
NS, not significant.
^aP<0.05 vs WT normal mice.
^bP<0.05 vs WT BDL mice.

Quick links

Search