Figure 1 | Laboratory Investigation

Figure 1

From: Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma

Figure 1

Nuclear localization of E-cadherin correlates with positive VHL immunostaining in CC-RCC. (a) CC-RCC TMA were immunostained with anti- E-cadherin antibody and scored for nuclear E-cadherin expression (left panel). Nuclear E-cadherin-positive CC-RCC samples were then scored for VHL immunoreactivity (right panel). (b) Immunohistochemical staining of a representative tumor tissue sample (patient no. 9) with VHL mutation using the indicated antibodies. (c) Immunohistochemical staining of a representative normal kidney tissue sample (patient no. 9), as well as representative samples on TMA slide constructed using quadruplicate samples from chromophobe and papillary RCC subtypes using the indicated antibodies. Notably, chromophobe RCC is known to express E-cadherin, while papillary RCC has been shown to be a non-expresser of E-cadherin.32

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