Abstract
What is the molecular basis of cell movement and changes in cell shape? The integration of three approaches is revealing how the molecular motors that drive these processes move and produce force.
Similar content being viewed by others
Enjoying our latest content?
Log in or create an account to continue
- Access the most recent journalism from Nature's award-winning team
- Explore the latest features & opinion covering groundbreaking research
or
References
Huxley, H. E. Harvey Lect. 60, 85–118 (1966).
Huxley, H. E. Science 164, 1356–1366 (1969).
Huxley, A. F. & Simmons, R. M. Nature 233, 533–538 (1971).
Huxley, A. F. J. Physiol., Lond. 243, 1–43 (1974).
Goodson, H. V. & Spudich, J. A. Proc. natn. Acad. Sci. U.S.A. 90, 659–663 (1993).
Cheney, R. E., Riley, M. A. & Mooseker, M. S. Cell Motil. Cytoskel. 24, 215–223 (1993).
Mabuchi, I. & Okuno, M. J. Cell Biol. 74, 251–263 (1977).
Kiehart, D. P. et al. EMBO J. 8, 913–922 (1989).
Knecht, D. A. & Loomis, W. F. Science 236, 1081–1086 (1987).
De Lozanne, A. & Spudich, J. A. Science 236, 1086–1091 (1987).
Pollard, T. P., Doberstein, S. K. & Zot, H. G. A. Rev. Physiol. 53, 653–681 (1991).
Korn, E. D. & Hammer, J. A. Curr. Op. Cell Biol. 2, 57–61 (1990).
Vale, R. D., Reese, T. S. & Sheetz, M. P. Cell 42, 39–50 (1985).
Vallee, R. B., Wall, J. S., Paschal, B. M. & Shpetner, H. S. Nature 332, 561–563 (1988).
Goldstein, L. S. A. Rev. Genet. 27, 319–351 (1993).
Vale, R. D. Trends biochem. Sci. 17, 300–304 (1992).
Spudich, J. A. Cell Reg. 1, 1–11 (1989).
Warrick, H. M. & Spudich, J. A. A. Rev. Cell Biol. 3, 379–421 (1987).
Harrington, W. F. & Rodgers, M. E. A. Rev. Biochem. 53, 35–73 (1984).
Hibberd, M. G. & Trentham, D. R. A. Rev. Biophys. biophys. Chem. 15, 119–161 (1986).
Cooke, R. Curr. Op. Cell Biol. 2, 62–66 (1990).
Lymn, R. W. & Taylor, E. W. Biochemistry 10, 4617–4624 (1971).
Taylor, E. W. CRC Crit. Rev. Biochem. 6, 103–164 (1979).
Siemankowski, R. F. & White, H. D. J. biol. Chem. 259, 5045–5053 (1984).
Uyeda, T. Q. P., Kron, S. J. & Spudich, J. A. J. molec. Biol. 214, 699–710 (1990).
Sheetz, M. P. & Spudich, J. A. Nature 303, 31–35 (1983).
Spudich, J. A., Kron, S. J. & Sheetz, M. P. Nature 315, 584–586 (1985).
Kron, S. J. & Spudich, J. A. Proc. natn. Acad. Sci. U.S.A. 83, 6272–6276 (1986).
Toyoshima, Y. Y. et al. Nature 328, 536–539 (1987).
Kishino, A. & Yanagida, T. Nature 334, 74–76 (1988).
Finer, J. T., Simmons, R. M. & Spudich, J. A. Nature 368, 113–119 (1994).
Ishijima, A. et al. Biochem. Biophys. Res. Commun. 199, 1057–1063 (1994).
Svoboda, K., Schmidt, C. F., Schnapp, B. J. & Block, S. M. Nature 365, 721–727 (1993).
Harada, Y., Sakurada, K., Aoki, T., Thomas, D. D. & Yanagida, T. J. molec. Biol. 216, 49–68 (1990).
Yanagida, T., Arata, T. & Oosawa, F. Nature 316, 366–369 (1985).
Higuchi, H. & Goldman, Y. E. Nature 352, 352–354 (1991).
Irving, M., Lombardi, V., Piazzesi, G. & Ferenczi, M. A. Nature 357, 156–158 (1992).
Saito, K., Aoki, T., Aoki, T. & Yanagida, T. Biophys. J. 66, 769–777 (1994).
Toyoshima, Y. Y., Kron, S. J. & Spudich, J. A. Proc. natn. Acad. Sci. U.S.A. 87, 7130–7134 (1990).
Uyeda, T. Q. P., Warrick, H. M., Kron, S. J. & Spudich, J. A. Nature 352, 307–311 (1991).
Ruppel, K. M., Uyeda, T. Q. P. & Spudich, J. A. J. biol. Chem. 269, 18773–18780 (1994).
Kabsch, W., Mannherz, H. G., Suck, D., Pai, E. F. & Holmes, K. C. Nature 347, 37–44 (1990).
Rayment, I. et al. Science 261, 50–58 (1993).
Xie, X. et al. Nature 368, 306–312 (1994).
Holmes, K. C., Popp, D., Gebhard, W. & Kabsch, W. Nature 347, 44–49 (1990).
Holmes, K. C., et al. Adv. exp. med. Biol. 332, 15–22 (1993).
Rayment, I. et al. Science 261, 58–65 (1993).
Schroeder, R. R. et al. Nature 364, 171–174 (1993).
Lowey, S., Waller, G. S. & Trybus, K. M. Nature 365, 454–456 (1993).
Uyeda, T. Q. P. & Spudich, J. A. Science 262, 1867–1870 (1993).
Itakura, S. et al. Biochem. Biophys. Res. Commun. 196, 1504–1510 (1993).
Uyeda, T. Q. P., Ruppel, K. M. & Spudich, J. A. Nature 368, 567–569 (1994).
Ma, Y.-Z. & Taylor, E. W. Biophys. J. 66, 1542–1553 (1994).
Barany, M. J. gen. Physiol. 50, 197–218 (1967).
Takahashi, M., Kawamoto, S. & Adelstein, R. S. J. biol. Chem. 267, 17864–17871 (1992).
Kelley, C. A., Takahashi, M., Yu, J. H. & Adelstein, R. S. J. biol. Chem. 268, 12848–12854 (1993).
Hackney, D. D. J. biol. Chem. 269, 16508–16511 (1994).
Gilbert, S. P. & Johnson, K. A. Biochemistry 33, 1951–1960 (1994).
Sadhu, A. & Taylor, E. W. J. biol. Chem. 267, 11352–11359 (1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Spudich, J. How molecular motors work. Nature 372, 515–518 (1994). https://doi.org/10.1038/372515a0
Issue date:
DOI: https://doi.org/10.1038/372515a0
This article is cited by
-
Electrostatic interaction of loop 1 and backbone of human cardiac myosin regulates the rate of ATP induced actomyosin dissociation
Journal of Muscle Research and Cell Motility (2022)
-
Alpha and beta myosin isoforms and human atrial and ventricular contraction
Cellular and Molecular Life Sciences (2021)
-
Suitability of Japanese codling as a raw material for surimi-based products revealed by primary sequence analysis of myosin heavy chain and thermal gel properties
Fisheries Science (2020)
-
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
Biophysical Reviews (2018)
-
A new myofilament contraction model with ATP consumption for ventricular cell model
The Journal of Physiological Sciences (2018)


