Figure 1
From: Response of Nasopharyngeal Carcinoma Cells to Epstein-Barr Virus Infection In Vitro
Localization of Epstein-Barr virus (EBV) DNA in Raji cells and EBV-infected nasopharyngeal carcinoma (NPC)-TW 01 cells by in situ PCR hybridization. A, Raji cells; B, uninfected NPC cells; C, NPC cells infected by EBV for 2 days; D, cells infected by EBV for 3 weeks. All cells were treated with in situ PCR hybridization to localize EBV DNA. In C, NPC-TW 01 cells show strong multiple granular reaction products (arrowheads) of EBV signal in their nuclei with a few uninfected cells (arrows). But in D, the EBV DNA signal is decreased markedly with some cells containing a few granular reaction products (arrowheads) and many others no reaction products (arrows). The positive control of Raji cells in A reveals strong granular reaction products of EBV signal in each cell, whereas the negative control of uninfected NPC cells in B reveals no EBV signal. (Bars in A-D, 20 μm.)
