Figure 11
From: The Tyrosine Kinase Inhibitor Tyrphostin AG 126 Reduces the Development of Colitis in the Rat
Immunohistochemical localization of P-selectin in the colon. Staining of colon tissue sections obtained from sham-operated rats with anti-ICAM-1 antibody showed a specific staining along vessels, demonstrating that ICAM-1 is constitutively expressed (A). Ileum section from sham-operated rats revealed no positive staining for P-selectin (B). Sections from DNBS-treated rats showed intense positive staining for ICAM-1 (D) and for P-selectin (E) on endothelial cells. The degree of endothelial staining for ICAM-1 (G) and for P-selectin (H) was markedly reduced in tissue sections obtained from Tyrphostin AG 126-treated rats. Panels C, F, and I represent the staining combination of panels A and B, D and E, and G and H, respectively. Original magnification, ×32. Figure is representative of at least 3 experiments performed on different experimental days.
