Figure 2
Expression of hepatocyte nuclear factors (HNFs) in normal liver (a to d), ductular cells (e to h), ductular hepatocytes (i to l), and regenerative hepatocytes (m to p). Each column shows HNF-1 (a, e, i, and m), HNF-4α (b, f, j, and n), HNF-3β (c, g, k, and o), and C/EBPα (d, h, l, and p), respectively. All HNFs are localized in the nucleus of normal (a to d) and regenerative hepatocytes (m to p). Although HNF-1 is expressed in the nucleus of normal BEC (a, arrow), HNF-4a is not expressed (b, arrow). HNFs are mostly expressed in the cytoplasm of ductular cells (e to h), whereas HNF-1 and HNF-4α are expressed in the cytoplasm and nucleus of ductular hepatocytes (i and j). ×135.
