Table 1 Table 1 Behavioural effects of Δ9−THC, anandamide and oleamide

From: Anandamide may mediate sleep induction

ED50 values

    

Test

Δ9-THC

Anandamide

Oleamide

Anandamide+oleamide

Open field (ambulation)

7.0

3.4

5.7

0.8

Ring immobility

2.3

5.0

18.9

2.9

Hypothermia

9.5

3.6

17.5

1.5

Hot plate

10.3

28.0

29.2

3.0

  1. Ten minutes after intraperitoneal injection, mice were tested in four ways to evaluate cannabinoid−induced effects6. For each drug, dose−response curves were obtained using 5−7 doses in the range 1−10 mg per kg body mass (n=4−7 mice for each dose). ED50values were calculated by nonlinear regression (Graphpad Prism). Anandamide+oleamide denotes anandamide in the presence of 7.5 mg oleamide per kg body mass.
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