Figure 1 | Modern Pathology

Figure 1

From: Distinguishing well-differentiated hepatocellular carcinoma from benign liver by the physical features of fine-needle aspirates

Figure 1

Comparison of benign hepatic lesions (left column) and well-differentiated HCC (right column). (top row): Fine-needle aspiration smears, ultrafast Papanicolaou stain, (bottom row): Cell blocks, reticulin stain. (a) Aspirate of benign hepatic lesions presented as the rigid cores when deposited on the slide and rolled with the smearing (left and center slides). Occasionally, it may be broken down into large tissue fragments when crushing force was used (right slide). (b) Their rigidity is because of the fortification of tissue by reticulin wrapping along single cell plate architecture. (c) The aspirate of well-differentiated HCC, most frequently but not always, presented as liquid droplets (arrow) when deposited on the slide and easily smeared into finely granular smear because of decreased reticulin (d).

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