Figure 1 | Modern Pathology

Figure 1

From: The diagnostic utility of immunohistochemistry and electron microscopy in distinguishing between peritoneal mesotheliomas and serous carcinomas: a comparative study

Figure 1

(a) Strong D2-40 reactivity is seen along the apical surface of the cells in a papillary mesothelioma. (b) Solid area of a mesothelioma reacting with the D2-40 antibody. In some cells, the reaction appears to be encircling the entire cell, whereas in others it is discontinuous. (c) Serous carcinoma metastatic to the peritoneum, showing an area of continuous D2-40 positivity along the apical cell membrane. (d) Papillary mesothelioma exhibiting strong podoplanin positivity on the apical surface of the cells. (e) In this mesothelioma stained for podoplanin, there is an irregular, discontinuous reactivity along the apical surface of the cells. Strong reactivity on the cell membrane of what appears to be intracytoplasmic lumens is also seen. (f) The same serous carcinoma as shown in Figure 1c demonstrating an area of podoplanin positivity.

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