Table 3 Expression profiles—endometrial carcinoma vs carcinoma-associated complex atypical hyperplasia vs carcinoma-associated normal endometrium

	EC ^a /CA-CAH ^b					EC^a/CA-NL^c					CA-CAH^b/CA-NL^c
	EC	CA-CAH	Difference	No	P	EC	CA-NL	Difference	No	P	CA-CAH	CA-NL	Difference	No	P
	Median	Median	Median			Median	Median	Median			Median	Median	Median
All carcinoma types combined
AIB1 (BD^d)	200	180	62.5	27	0.007	200	90	60	37	<0.0001	190	150	10	18	0.072
Her2neu	1	1	0	25	0.036	1	0	1	30	0.0002	0	0	0	11	0.500
PRB-N	135	200	−55	24	0.041	90	300	−120	33	<0.0001	100	300	0	9	0.125
PRB-C	180	200	0	24	0.775	185	200	−50	34	0.014	250	300	0	10	0.563
ER	260	300	−30	25	0.064	250	300	−30	31	<0.0001	300	300	0	9	0.500
PR (total)	257.5	300	0	24	0.498	240	300	−42.5	30	0.003	285	300	−10	10	0.313
Type I carcinomas
AIB1 (BD^d)	200	160	20	20	0.107	200	80	80	29	0.0002	190	120	10	14	0.016
Her2neu	1	1	0	20	0.016	1	0	1	24	0.0003	0	0	0	8	0.500
PRB-N	120	200	−70	20	0.056	80	300	−135	28	<0.0001	100	300	−100	7	0.125
PRB-C	145	200	0	20	0.519	170	200	−50	29	0.036	150	300	0	8	0.500
ER	225	300	−30	20	0.040	250	300	−40	26	0.0001	300	300	0	7	0.500
PR (total)	250	300	0	20	0.636	240	300	−45	25	0.012	225	300	−25	8	0.313
Type II carcinomas
AIB1 (BD^d)	300	180	120	7	0.063	220	160	40	8	0.063	190	160	10	4	1.00
Her2neu	0	0	0	5	1.00	0	0	0	6	1.00	0	0	—	3	—
PRB-N	195	230	10	4	1.00	180	300	−120	5	0.25	300	300	—	2	—
PRB-C	272.5	245	47.5	4	0.500	200	300	−100	5	0.313	300	250	50	2	1.00
ER	270	300	0	5	0.750	270	300	0	5	0.75	300	300	—	2	—
PR (total	270	250	−7.5	4	0.75	285	300	−15	5	0.25	300	300	—	2	—

PRB-N=PR-B isoform nuclear expression; PRB-C=PR-B isoform cytoplasmic expression; No=Number. Comparison is between cases that had both types of tissue.
^aEndometrial carcinoma;
^bCarcinoma-associated complex atypical hyperplasia;
^cCarcinoma-associated normal endometrium.
^dBD Bioscience.
Bold values indicate statistically significant P-values.

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