Table 1 Comparison between immunostaining results for KIT and clinicopathologic variables in extrahepatic bile duct carcinoma
Variable (case number, total N=289) | Cytoplasmic KIT expression | P-value | Nuclear KIT expression | P-value |
|---|---|---|---|---|
Sex | ||||
Male (N=207) | 37 | 0.34 | 46 | 0.10 |
Female (N=82) | 17 | 12 | ||
Growth pattern | ||||
Papillary (N=34) | 12 | 0.03* | 8 | 0.71 |
Nodular (N=19) | 4 | 3 | ||
Infiltrative (N=236) | 38 | 47 | ||
Differentiation | ||||
Well differentiated (N=94) | 16 | 0.81 | 15 | 0.23 |
Moderately differentiated (N=149) | 30 | 30 | ||
Poorly differentiated (N=46) | 8 | 13 | ||
T classification | ||||
T1 (N=48) | 12 | 0.04* | 9 | 0.66 |
T2 (N=105) | 13 | 23 | ||
T3 (N=110) | 27 | 19 | ||
T4 (N=26) | 2 | 7 | ||
Duodenal invasion | ||||
Absent (N=263) | 52 | 0.10 | 51 | 0.25 |
Present (N=26) | 2 | 7 | ||
Hepatic invasion | ||||
Absent (N=277) | 51 | 0.39 | 57 | 0.09 |
Present (N=12) | 3 | 1 | ||
Pancreatic invasion | ||||
Absent (N=165) | 28 | 0.24 | 32 | 0.43 |
Present (N=124) | 26 | 26 | ||
Perineural invasion | ||||
Absent (N=94) | 21 | 0.17 | 20 | 0.42 |
Present (N=195) | 33 | 38 | ||
Vascular invasion | ||||
Absent (N=210) | 42 | 0.22 | 31 | <0.001* |
Present (N=79) | 12 | 27 | ||
Lymph node metastasis | ||||
Absent (N=197) | 37 | 0.54 | 39 | 0.49 |
Present (N=92) | 17 | 19 | ||
Resection marginal status | ||||
Negative (N=225) | 46 | 0.10 | 43 | 0.28 |
Positive (N=64) | 8 | 15 | ||
Stage grouping | ||||
Stage IA (N=41) | 10 | 0.06 | 8 | 0.92 |
Stage IB (N=74) | 8 | 15 | ||
Stage IIA (N=70) | 19 | 13 | ||
Stage IIB (N=78) | 15 | 15 | ||
Stage III (N=26) | 2 | 7 | ||
