Table 2 Univariate analysis of survival by clinicopathologic variables in patients with extrahepatic bile duct carcinoma

Factor	Characteristics	Number	Median survival (months)	P-value
Sex	Male	145	34	0.46
	Female	57	27
Size^a	2.5^b	202	33^c	0.18
Growth pattern	Papillary	25	53	0.001^*
	Nodular	17	—
	Infiltrative	160	29
T classification	T1	41	—	<0.001^*
	T2	65	29
	T3	86	27
	T4	10	13
Lymph node metastasis	Present	65	18	<0.001^*
	Absent	137	45
Hepatic invasion	Present	11	18	0.23
	Absent	191	33
Pancreatic invasion	Present	84	27	0.03^*
	Absent	118	41
Duodenal invasion	Present	10	13	0.003^*
	Absent	192	35
Resection marginal status	Positive	44	20	0.04^*
	Negative	158	38
Perineural invasion	Present	137	29	0.07
	Absent	65	50
Vascular invasion	Present	48	19	0.002^*
	Absent	154	42
KIT expression	Present	49	Not determined	0.01^*
	Absent	153	30

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