FIGURE 1
From: Clonality of Precursors of Cervical Cancer and Their Genetical Links to Invasive Cancer
Four micrographs showing the morphology of lesions C40, C50, and C54. X-chromosome inactivation pattern was assessed by comparing electrophoretic signal intensity of the sample with (+) or without (−) HhaI digestion. Case C54 had a polyclonal signal in normal epithelium (n−; n+) and had a monoclonal one in cervical intraepithelial neoplasia (CIN) II (E−; E+) (A). C40 had equal signal intensity of both alleles in normal tissue (N−; N+) and significant reduction of the long allele CIN III (F−; F+) (B). Case C50 showed polyclonal signal in normal tissue (N−; N+), in CIN II (E−; E+) (C), and in CIN III (F−; F+) (D) (original magnification, ×200).
