FIGURE 3
From: Clonality of Precursors of Cervical Cancer and Their Genetical Links to Invasive Cancer

Results of clonal relationships between multiple synchronous neoplastic lesions of the cervix in five cases. Clonality analyses were performed as indicated in “Materials and Methods” section. Identical X-chromosome inactivation patterns between invasive cancer and coexisted cervical intraepithelial neoplasia (CIN) lesions were found in C27, C82, and C83, whereas different patterns were observed in C26, C76, and C83. N, normal tissue; n, normal epithelium; E, CIN II; F, CIN III; G, carcinoma in situ; T, invasive cancer; − and +, without and with HhaI-digestion before polymerase chain reaction amplification.