TABLE 1 Summary of Clonality and HPV Status in Cervices without (Group A) and with (Group B) Coexisting Invasive Cancer

From: Clonality of Precursors of Cervical Cancer and Their Genetical Links to Invasive Cancer

Cases

Normal Control

Clonality of Lesions

HPV Detection

 

Tissue Type

Chromosome X- Inactivation Pattern

CIN I

CIN II

CIN IIIa

CIN IIIb

Invasive Cancer

 

Group A

        

C34

Normal epith

Mono 1

  

Mono 2

  

31

C36

Normal epith

Mono 1

 

Mono 2

   

Negative

C40

Normal tissue

Poly

  

Mono 1

  

Not done

C43

Normal tissue

Poly

 

Mono 1

   

Negative

C44

Normal epith

Poly

 

Poly

Poly

  

Not done

C45

Normal epith

Mono 2

 

Mono 2

   

58*

C50

Normal tissue

Poly

 

Poly

Poly

  

33

C51

Normal epith

Mono 1

  

Mono 1

Mono 1

 

16*

C53

Normal tissue

Poly

Poly

    

Negative

C54

Normal epith

Poly

 

Mono 2

   

58

C57

Normal epith

Poly

  

Mono 1

  

Negative

C60

Normal tissue

Mono 1

 

Mono 2

   

58*

Group B

        

C04

Normal tissue

Poly

  

Mono 1

 

Mono 1

Not done

C26

Normal tissue

Poly

  

Mono 1

 

Mono 2

16*

C27

Normal epith

Mono 1

  

Mono 2

 

Mono 2

16*

C28

Normal tissue

Mono 1

  

Mono 1

 

Mono 1

Not done

C58

Normal epith

Mono 1

 

Mono 1

Mono 1

 

Mono 1

16*

C76

Normal epith

Mono 2

  

Mono 2

 

Mono 1

16*

C82

Normal epith

Poly

 

Mono 1

  

Mono 1

16

C83

Normal tissue

Mono 1

 

Mono 2

Mono 1

 

Mono 1

Other*

C88

Normal tissue

Poly

Mono 1

   

Mono 1

16

C89

Normal epith

Mono 1

  

Mono 1

 

Mono 1

18

  1. HPV, human papillomavirus; CIN, cervical intraepithelial neoplasia; Normal epith, normal cervical squamous epithelia; Normal tissue, normal cervical tissues; Poly, polyclonality; Mono 1, monoclonality with shorter AR allele; Mono 2, monoclonality with longer allele. *, identical HPV type was found in all lesions as well as normal control tissue in individual case.
  2. Normal cervical squamous epithelia were preferentially selected as normal control for clonality analysis. In the cases in which samples from normal cervical squamous epithelia were unamplified, normal cervical tissues mixed with stromas and epithelia were used as a control.