TABLE 5 Correlation of Immunophenotypic Profiles, Grade, and Genotype for Diffuse Large B-Cell Lymphomas

From: Immunophenotypic and Genotypic Markers of Follicular Center Cell Neoplasia in Diffuse Large B-Cell Lymphomas

 

Total

CD138+

CD138−

Bcl-2-Ra, d

Bcl-6-Rd

bcl-6+, bcl-2+, CD10+

17

3/16b

13/16

3/10

3/9

bcl-6+, bcl-2+, CD10−

12

0

12

0/7

3/7

bcl-6+, bcl-2−, CD10+

6

0

6

0/4

1/4

bcl-6+, bcl-2−, CD10−

2c

0

2

1/2

0/2

bcl-6−, bcl-2+, CD10−

1

0

1

0/0

0/0

bcl-6−, bcl-2+, CD10+

2

0

2

0/0

0/0

  1. aBcl-2R were identified in 1/4 cases not included in this table. The bcl-2R-positive case was bcl-2+, CD138 equivocal and bcl-6 and CD10 staining could not be tested. One of these cases considered bcl-2R-negative showed a weak mcr rearrangement by Southern blot analysis but it could not be confirmed by polymerase chain reaction. Bcl-6R were identified in 0/4 additional cases.
  2. bIn one case, the bcl-6 staining was mostly in CD20+ CD10+ vaguely nodular areas that included multilobate cells and the CD138 positivity was in the intervening areas that were mostly bcl-6 negative, mostly CD20 negative and showed only some CD10 positivity. Bcl-2 staining was more marked in the latter areas also. A bcl-6/CD138 double stain did not demonstrate any definite double-stained cells (data not shown). In the other two cases, the bcl-6 positivity was uniform and the CD138 staining patchy.
  3. cOne case considered negative showed equivocal bcl-2 staining.
  4. dOnly includes results for cases with documented immunoglobulin heavy chain rearrangement.
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