FIGURE 2 | Modern Pathology

FIGURE 2

From: Transition from In Situ to Invasive Testicular Germ Cell Neoplasia is Associated with the Loss of p21 and Gain of mdm-2 Expression

FIGURE 2

A proposed model for p53/p21/mdm-2 regulation in germ cell tumors. A, Intratubular germ cell neoplasia (ITGCN): p53 induces p21 in the absence of mdm-2. p21 binds and inactivates cyclin/cdk complexes and inhibits their activity, resulting in cell cycle arrest. B, Invasive tumor: mdm-2 binds p53 and blocks induction of p21, allowing for cyclin/cdk activity and continued cellular proliferation.

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