FIGURE 1 | Modern Pathology

FIGURE 1

From: Reliability of Tissue Microarrays in Detecting Protein Expression and Gene Amplification in Breast Cancer

FIGURE 1

Representative examples of ER, PR, and c-erbB2 immunohistochemistry and HER-2/neu gene amplification (FISH) in breast tumor tissue arrays. a, d, g,and j, H&E staining of four tissue samples (× 42); b, e,and h, immunostaining (× 42); c, f,and i, enlarged immunostaining of the specific area (× 200); k, a tissue microarray sample for FISH analysis (× 100); l, HER-2/neu gene amplification (× 1000): cells showing a massive increase in the number of the orange signals as compared with the green internal control signals.

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