Unaltered susceptibility to BSE in transgenic mice expressing human prion protein

Nature 378, 779–783 (1995)

In this Letter we reported that transgenic mice expressing both human and mouse prion protein are no more susceptible to BSE than their wild-type counterparts. We also included the interim results of challenge of mice expressing only human prion protein (HuPrP^+/+Prn-p^o/o) with BSE; these mice had remained disease-free 264 days post-inoculation. We have now found that from 489 days onwards, some of these HuPrP^+/+ Prn-p^o/o mice developed a prion disease. More details appear on pages 448–450 of this issue.

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