The ability to perform laboratory operations on a small scale using miniaturized (lab-on-a-chip) devices is very appealing. Small volumes reduce the time taken to synthesize and analyse a product; the unique behaviour of liquids at the microscale allows greater control of molecular concentrations and interactions; and reagent costs and the amount of chemical waste can be much reduced. Compact devices also allow samples to be analysed at the point of need rather than a centralized laboratory.

Initially, however, pioneers of the field asked in Chimia whether their ideas about miniaturization would be “next century's technology or just a fashionable craze”. The advantages are compelling, but designing and making devices of reduced size that operate effectively is challenging. The pioneers recognized the huge financial input and research effort needed to realize the full potential of the concept.

Enjoying our latest content?
Log in or create an account to continue

  • Access the most recent journalism from Nature's award-winning team
  • Explore the latest features & opinion covering groundbreaking research
Access through your institution

or

Sign in or create an account
Continue with Google
Continue with ORCiD