Abstract
At the 4th International Meeting on Single Nucleotide Polymorphism and Complex Genome Analysis (Stockholm, Sweden, 10th-14th October 2001), approximately 100 scientists from more than 20 nations undertook a probing review of latest developments in the field. Despite impressive and still ongoing activities towards SNP discovery and validation, plus efforts towards haplotype exploitation, it was clear that supporting technologies for genotyping are way behind where they need to be. Innate complexity and large variances in aspects of genome function together pose immense challenges that are difficult to surmount in the human situation. In contrast, studies in simpler organisms and population/evolutionary genetics studies are yielding important new insights. Breakthroughs that are being made in understanding the genetic etiology of complex disease tend to involve genes of larger effect or extremely well merited candidates. Linkage studies and proximal phenotypes are being recommended, though the best way forward is still hotly debated. Consequently, many diverse and ambitious projects are underway, from which the data itself will eventually show what is and is not possible.
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Acknowledgements
The meeting was sponsored principally by the Swedish Wenner-Gren Foundations, who also included it in their own Symposium Series and hosted the whole event at their conference center. Additionally, Orchid BioSciences volunteered significant additional funds to cover all extra costs.
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Brookes, A. 4th International Meeting on Single Nucleotide Polymorphism and Complex Genome AnalysisVarious Uses for DNA Variations. Eur J Hum Genet 10, 153–155 (2002). https://doi.org/10.1038/sj.ejhg.5200774
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DOI: https://doi.org/10.1038/sj.ejhg.5200774
