Abstract
The UK Department of Health supported the establishment of the UK Genetic Testing Network (UKGTN) in 2002. The UKGTN is a collaborative network of NHS molecular genetic laboratories that offer tests for human single gene germ-line disorders. Its objective is to provide high quality and equitable services for patients and their families who require genetic advice, diagnosis and management. The UKGTN has developed a ‘Gene Dossier’ process to evaluate genetic tests and recommend which tests will be provided by the National Health Service. This paper describes the UKGTN organisation and the ‘Gene Dossier’ process. A brief review of the UKGTN genetic test evaluation experience is presented.
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Acknowledgements
We thank Tim Smedley, UKGTN Project Manager, for providing details of the gene dossiers that were rejected and his comments on aspects of the gene dossier process.
PF is Chair of the UKGTN, RZ is Chair of the UKGTN Service Development Working Group, FS is Chair of the UKGTN Gene Dossier (Test evaluation) Working Group, JW is UKGTN Scientific Expert Advisor and MK is UKGTN Public Health Expert Advisor.
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Kroese, M., Zimmern, R., Farndon, P. et al. How can genetic tests be evaluated for clinical use? Experience of the UK Genetic Testing Network. Eur J Hum Genet 15, 917–921 (2007). https://doi.org/10.1038/sj.ejhg.5201867
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DOI: https://doi.org/10.1038/sj.ejhg.5201867
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